Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0202) | |||||
|---|---|---|---|---|---|
| DME Name | Fatty acid desaturase 1 (FADS1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.19.44 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FADS1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypermethylation p-value: 2.34E-05; delta-beta: 2.48E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FADS1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Fatty acid desaturase 1. As a result, the interaction between DNMT and FADS1 can moderatly affect the drug-metabolizing process of Fatty acid desaturase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.