Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0203)
DME Name	Fatty acid desaturase 2 (FADS2), Homo sapiens	DME Info
UniProt ID	FADS2_HUMAN
EC Number	EC: 1.14.19.3 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Oxygen paired donor oxidoreductase EC: 1.14.19.3
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypermethylation
Interaction Name	DNMT-FADS2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 9.81E-08; delta-beta: 3.18E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FADS2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Fatty acid desaturase 2. As a result, the interaction between DNMT and FADS2 can significantly affect the drug-metabolizing process of Fatty acid desaturase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone acetyltransferases (HATs)		Liver cancer		Activation
Uniprot ID	HAT1_HUMAN
Interaction Name	HATs-FADS2 interaction				[1]
Studied Cell Lines	HCC cell line
Description	Histone acetyltransferases (HATs) are reported to acetylate the FADS2 gene and thereby activate the transcriptional activity of the drug-metabolizing enzyme Fatty acid desaturase 2. As a result, the interaction between HATs and FADS2 can enhance the drug-metabolizing process of Fatty acid desaturase 2.
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypermethylation
Interaction Name	DNMT-FADS2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.22E-02; delta-beta: 3.52E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FADS2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Fatty acid desaturase 2. As a result, the interaction between DNMT and FADS2 can significantly affect the drug-metabolizing process of Fatty acid desaturase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis. J Virol. 2015 Jan;89(1):605-14.

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