Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0206)
DME Name Sodium/potassium-transporting ATPase gamma (FXYD2), Homo sapiens DME Info
UniProt ID
ATNG_HUMAN
EC Number    EC: 3.6.1.-     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Acid anhydride hydrolase
Acid anhydride hydrolase
EC: 3.6.1.-
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Significant hypomethylation
Interaction Name DNMT-FXYD2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 9.97E-11; delta-beta: -3.88E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FXYD2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sodium/potassium-transporting ATPase gamma. As a result, the interaction between DNMT and FXYD2 can significantly affect the drug-metabolizing process of Sodium/potassium-transporting ATPase gamma.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
      ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
               ICD-11: 5C50 Phenylketonuria Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Dimerization cofactor of HNF1 (PCBD1) Hyperphenylalaninemia Repression
Uniprot ID
PHS_HUMAN
Interaction Name PCBD1-FXYD2 interaction [1]
Studied Cell Lines HEK293 cell line
Description Dimerization cofactor of HNF1 (PCBD1) is reported to repress the transcription of FXYD2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Sodium/potassium-transporting ATPase gamma. As a result, the interaction between PCBD1 and FXYD2 can repress the drug-metabolizing process of Sodium/potassium-transporting ATPase gamma.
               ICD-11: 5C59 Primapterinuria Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Dimerization cofactor of HNF1 (PCBD1) Primapterinuria Repression
Uniprot ID
PHS_HUMAN
Interaction Name PCBD1-FXYD2 interaction [1]
Studied Cell Lines HEK293 cell line
Description Dimerization cofactor of HNF1 (PCBD1) is reported to repress the transcription of FXYD2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Sodium/potassium-transporting ATPase gamma. As a result, the interaction between PCBD1 and FXYD2 can repress the drug-metabolizing process of Sodium/potassium-transporting ATPase gamma.
References
1 Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol. 2014 Mar;25(3):574-86.

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