| General Information of Drug-Metabolizing Enzyme (DME ID: DME0208) |
| DME Name |
Oleamide hydrolase 1 (FAAH), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.1.99 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amide hydrolase
EC: 3.5.1.99
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| STAT 3 (STAT3) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
STAT3-FAAH interaction |
[1] |
| Studied Cell Lines |
Human T lymphocytes |
| Ensembl ID |
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| Description |
STAT 3 (STAT3) is reported to activate the transcription of FAAH gene, which leads to an increased expression of the drug-metabolizing enzyme Oleamide hydrolase 1. As a result, the interaction between STAT3 and FAAH can activate the drug-metabolizing process of Oleamide hydrolase 1. |
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| References |
| 1 |
Leptin Activates the Anandamide Hydrolase Promoter in Human T Lymphocytes Through STAT3 J Biol Chem. 2003 Apr 11;278(15):13318-24.
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