Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0212) | |||||
|---|---|---|---|---|---|
| DME Name | Acetyl-CoA synthetase (ACSS2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 6.2.1.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 01 Infectious/parasitic diseases | |||||
| ICD-11: 1C60 Human immunodeficiency virus infection | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| Histone modification | |||||
| Histone deacetylases (HDACs) | Human immunodeficiency virus infection | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HDACs-ACSS2 interaction | [1] | |||
| Studied Cell Lines | Human CD4+ T cells | ||||
| Description | Histone deacetylases (HDACs) are reported to deacetylate the ACSS2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between HDACs and ACSS2 can inhibit the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
| Histone methyltransferases (HMTs) | Human immunodeficiency virus infection | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HMTs-ACSS2 interaction | [1] | |||
| Studied Cell Lines | Human CD4+ T cells | ||||
| Description | Histone methyltransferases (HMTs) are reported to hyper-methylate the ACSS2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between HMTs and ACSS2 can inhibit the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.94E-02; delta-beta: -2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACSS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can moderatly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.49E-02; delta-beta: 3.99E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ACSS2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can significantly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Vestibular melanotic schwannoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.30E-05; delta-beta: -2.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACSS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can moderatly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.63E-02; delta-beta: -2.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACSS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can moderatly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.82E-15; delta-beta: -2.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACSS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can moderatly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-ACSS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.48E-02; delta-beta: 4.04E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ACSS2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Acetyl-CoA synthetase. As a result, the interaction between DNMT and ACSS2 can significantly affect the drug-metabolizing process of Acetyl-CoA synthetase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| References | |||||
|---|---|---|---|---|---|
| 1 | HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 2018 Mar 1;128(3):1190-1198. | ||||
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