Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0213) | |||||
|---|---|---|---|---|---|
| DME Name | Hydroxyacid-oxoacid transhydrogenase (ADHFE1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.99.24 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ADHFE1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.44E-25; delta-beta: 7.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADHFE1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can significantly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-ADHFE1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.30E-14; delta-beta: 2.19E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ADHFE1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can moderatly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-ADHFE1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.61E-29; delta-beta: 2.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ADHFE1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can moderatly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 5.10E-25; delta-beta: 3.52E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADHFE1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can significantly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-ADHFE1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.55E-24; delta-beta: 3.89E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADHFE1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can significantly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 5.85E-04; delta-beta: 3.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADHFE1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can significantly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-ADHFE1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.97E-03; delta-beta: 7.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADHFE1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Hydroxyacid-oxoacid transhydrogenase. As a result, the interaction between DNMT and ADHFE1 can significantly affect the drug-metabolizing process of Hydroxyacid-oxoacid transhydrogenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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