General Information of Drug-Metabolizing Enzyme (DME ID: DME0214)
DME Name Succinate-semialdehyde dehydrogenase (ALDH5A1), Homo sapiens DME Info
UniProt ID
SSDH_HUMAN
EC Number    EC: 1.2.1.24     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.24
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-29a-3p Liver cancer Suppression
miRBase ID
MIMAT0000086
Interaction Name hsa-miR-29a-3p--ALDH5A1 regulation [1]
Studied Cell Lines HepaRG cell line
Description hsa-miR-29a-3p is reported to suppress ALDH5A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALDH5A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Succinate-semialdehyde dehydrogenase.
               ICD-11: 2C25 Lung cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-147b Lung cancer Suppression
miRBase ID
MI0005544
Interaction Name hsa-miR-147b--ALDH5A1 regulation [2]
Studied Cell Lines A549 cell line
Description hsa-miR-147b is reported to suppress ALDH5A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALDH5A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Succinate-semialdehyde dehydrogenase.
                            hsa-miR-210-3p Lung cancer Suppression
miRBase ID
MIMAT0000267
Interaction Name hsa-miR-210-3p--ALDH5A1 regulation [2]
Studied Cell Lines A549 cell line
Description hsa-miR-210-3p is reported to suppress ALDH5A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALDH5A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Succinate-semialdehyde dehydrogenase.
References
1 Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells. Biochem Pharmacol. 2015 Dec 15;98(4):671-80.
2 "Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity. PLoS One. 2012;7(9):e44919.

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