Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0216) | |||||
|---|---|---|---|---|---|
| DME Name | Putrescine acetyltransferase (SSAT1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.57 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.02E-11; delta-beta: -2.63E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.60E-03; delta-beta: -2.55E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.89E-09; delta-beta: -6.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.99E-30; delta-beta: -2.47E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.58E-14; delta-beta: -3.66E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.24E-05; delta-beta: -2.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| Transcription-factor regulation | |||||
| PPA receptor delta (PPARD) | Colorectal cancer | Activation | |||
| Uniprot ID | |||||
| Interaction Name | PPARD-SAT1 interaction | [1] | |||
| Studied Cell Lines | Caco-2 cell line | ||||
| Ensembl ID | |||||
| Description | PPA receptor delta (PPARD) is reported to activate the transcription of SSAT1 gene, which leads to an increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between PPARD and SSAT1 can activate the drug-metabolizing process of Putrescine acetyltransferase. | ||||
| PPA receptor gamma (PPARG) | Colorectal cancer | Activation | |||
| Uniprot ID | |||||
| Interaction Name | PPARG-SAT1 interaction | [1] | |||
| Studied Cell Lines | Caco-2 cell line | ||||
| Ensembl ID | |||||
| Description | PPA receptor gamma (PPARG) is reported to activate the transcription of SSAT1 gene, which leads to an increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between PPARG and SSAT1 can activate the drug-metabolizing process of Putrescine acetyltransferase. | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.82E-04; delta-beta: 2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 4.48E-02; delta-beta: 2.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 1.08E-04; delta-beta: -2.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can moderatly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.63E-16; delta-beta: -7.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.61E-119; delta-beta: -3.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.72E-10; delta-beta: -4.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypermethylation | |||
| Interaction Name | DNMT-SSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 7.51E-15; delta-beta: 4.26E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Putrescine acetyltransferase. As a result, the interaction between DNMT and SSAT1 can significantly affect the drug-metabolizing process of Putrescine acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| References | |||||
|---|---|---|---|---|---|
| 1 | Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75. | ||||
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