Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0218) | |||||
|---|---|---|---|---|---|
| DME Name | Steroid 5-alpha-reductase 2 (SRD5A2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.3.1.22 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 7.92E-07; delta-beta: 3.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SRD5A2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can significantly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.04E-33; delta-beta: 2.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.13E-11; delta-beta: 2.55E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Acute myeloid leukemia | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.32E-09; delta-beta: 2.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.52E-28; delta-beta: 4.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SRD5A2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can significantly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 1.45E-02; delta-beta: 2.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 6.44E-10; delta-beta: 2.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.91E-02; delta-beta: 4.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SRD5A2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can significantly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypermethylation | |||
| Interaction Name | DNMT-SRD5A2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 4.94E-02; delta-beta: 2.19E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SRD5A2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Steroid 5-alpha-reductase 2. As a result, the interaction between DNMT and SRD5A2 can moderatly affect the drug-metabolizing process of Steroid 5-alpha-reductase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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