Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0222)
DME Name	Beta-HSD adrenal and gonadal type (HSD3B2), Homo sapiens	DME Info
UniProt ID	3BHS2_HUMAN
EC Number	EC: 1.1.1.145 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.145
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.45E-11; delta-beta: -4.93E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD3B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can significantly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypomethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.16E-17; delta-beta: -5.30E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD3B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can significantly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Third ventricle chordoid glioma		Moderate hypermethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.67E-02; delta-beta: 2.69E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the HSD3B2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can moderatly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Significant hypermethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.85E-04; delta-beta: 4.61E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the HSD3B2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can significantly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Nuclear receptor family 5 A2 (NR5A2)		Lung cancer		Activation
Uniprot ID	NR5A2_HUMAN
Interaction Name	NR5A2-HSD3B2 interaction				[1]
Studied Cell Lines	HEC-1A cell line
Ensembl ID	ENSG00000116833
Description	Nuclear receptor family 5 A2 (NR5A2) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between NR5A2 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
Steroidogenic factor 1 (NR5A1)		Lung cancer		Activation
Uniprot ID	STF1_HUMAN
Interaction Name	NR5A1-HSD3B2 interaction				[1]
Studied Cell Lines	HEC-1A cell line
Ensembl ID	ENSG00000136931
Description	Steroidogenic factor 1 (NR5A1) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between NR5A1 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
ICD-11: 2C76 Endometrial cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Nuclear receptor family 5 A2 (NR5A2)		Endometrial cancer		Activation
Uniprot ID	NR5A2_HUMAN
Interaction Name	NR5A2-HSD3B2 interaction				[1]
Studied Cell Lines	Ishikawa cell line
Ensembl ID	ENSG00000116833
Description	Nuclear receptor family 5 A2 (NR5A2) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between NR5A2 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
Steroidogenic factor 1 (NR5A1)		Endometrial cancer		Activation
Uniprot ID	STF1_HUMAN
Interaction Name	NR5A1-HSD3B2 interaction				[1]
Studied Cell Lines	Ishikawa cell line
Ensembl ID	ENSG00000136931
Description	Steroidogenic factor 1 (NR5A1) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between NR5A1 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Transcriptional repressor YY1 (YY1)		Prostate cancer		Activation
Uniprot ID	TYY1_HUMAN
Interaction Name	YY1-HSD3B2 interaction				[2]
Studied Cell Lines	LNCap cell line
Ensembl ID	ENSG00000100811
Description	Transcriptional repressor YY1 (YY1) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between YY1 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
ICD-11: 2D11 Adrenocortical carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Transcriptional repressor YY1 (YY1)		Adrenocortical carcinoma		Activation
Uniprot ID	TYY1_HUMAN
Interaction Name	YY1-HSD3B2 interaction				[2]
Studied Cell Lines	SW-13 cell line
Ensembl ID	ENSG00000100811
Description	Transcriptional repressor YY1 (YY1) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between YY1 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Moderate hypomethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.15E-02; delta-beta: -2.19E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD3B2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can moderatly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Posterior fossa ependymoma		Moderate hypomethylation
Interaction Name	DNMT-HSD3B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.20E-26; delta-beta: -2.59E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD3B2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between DNMT and HSD3B2 can moderatly affect the drug-metabolizing process of Beta-HSD adrenal and gonadal type.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F37 Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Nuclear receptor family 4 A1 (NR4A1)		Pituitary adenoma		Activation
Uniprot ID	NR4A1_HUMAN
Interaction Name	NR4A1-HSD3B2 interaction				[3]
Studied Cell Lines	H295R adrenocortical cell line
Ensembl ID	ENSG00000123358
Description	Nuclear receptor family 4 A1 (NR4A1) is reported to activate the transcription of HSD3B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Beta-HSD adrenal and gonadal type. As a result, the interaction between NR4A1 and HSD3B2 can activate the drug-metabolizing process of Beta-HSD adrenal and gonadal type.

References
1	The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors. Cancer Lett. 2009 Mar 8;275(1):127-38.
2	YY1 binding within the human HSD3B2 gene intron 1 is required for maximal basal promoter activity: identification of YY1 as the 3beta1-A factor. J Mol Endocrinol. 2004 Aug;33(1):99-119.
3	A role for the NGFI-B family in adrenal zonation and adrenocortical disease. Endocr Res. 2004 Nov;30(4):567-74.

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