Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0224)
DME Name	HMG-CoA reductase (HMGCR), Homo sapiens	DME Info
UniProt ID	HMDH_HUMAN
EC Number	EC: 1.1.1.34 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.34
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 13 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Glioblastoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.18E-07; delta-beta: -4.20E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Anaplastic pilocytic astrocytoma		Moderate hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.84E-07; delta-beta: -2.53E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HMGCR gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can moderatly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Low grade glioma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 7.93E-28; delta-beta: -4.04E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.33E-18; delta-beta: -6.88E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Malignant astrocytoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.01E-33; delta-beta: -4.79E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Mixed neuronal-glial tumour		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 5.50E-14; delta-beta: -4.58E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Brain neuroepithelial tumour		Moderate hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.02E-05; delta-beta: -2.52E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HMGCR gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can moderatly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Myxopapillary ependymoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.68E-14; delta-beta: -3.97E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		RELA YAP fusion ependymoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.26E-40; delta-beta: -5.91E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.49E-45; delta-beta: -5.38E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Third ventricle chordoid glioma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.15E-02; delta-beta: -4.59E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Spinal ependymoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 7.31E-14; delta-beta: -4.16E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Anaplastic pleomorphic xanthoastrocytoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 7.56E-03; delta-beta: -3.30E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
Non-coding RNA regulation
hsa-miR-27a-3p		Liver cancer		Suppression
miRBase ID	MIMAT0000084
Interaction Name	hsa-miR-27a-3p--HMGCR regulation				[1]
Studied Cell Lines	Huh7 cell line
Description	hsa-miR-27a-3p is reported to suppress HMGCR mRNA translation by binding to the 3' untranslated region (3'UTR) of HMGCR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme HMG-CoA reductase.
hsa-miR-29a-3p		Liver cancer		Suppression
miRBase ID	MIMAT0000086
Interaction Name	hsa-miR-29a-3p--HMGCR regulation				[2]
Studied Cell Lines	HepG2 cell line
Description	hsa-miR-29a-3p is reported to suppress HMGCR mRNA translation by binding to the 3' untranslated region (3'UTR) of HMGCR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme HMG-CoA reductase.
hsa-miR-29b-3p		Liver cancer		Suppression
miRBase ID	MIMAT0000100
Interaction Name	hsa-miR-29b-3p--HMGCR regulation				[2]
Studied Cell Lines	HepG2 cell line
Description	hsa-miR-29b-3p is reported to suppress HMGCR mRNA translation by binding to the 3' untranslated region (3'UTR) of HMGCR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme HMG-CoA reductase.
hsa-miR-29c-3p		Liver cancer		Suppression
miRBase ID	MIMAT0000681
Interaction Name	hsa-miR-29c-3p--HMGCR regulation				[2]
Studied Cell Lines	HepG2 cell line
Description	hsa-miR-29c-3p is reported to suppress HMGCR mRNA translation by binding to the 3' untranslated region (3'UTR) of HMGCR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme HMG-CoA reductase.
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Posterior fossa ependymoma		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.18E-75; delta-beta: -6.56E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypomethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.65E-04; delta-beta: -4.04E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HMGCR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BD51 Arterial aneurysm		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Arterial aneurysm		Significant hypermethylation
Interaction Name	DNMT-HMGCR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.47E-03; delta-beta: 4.67E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the HMGCR gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between DNMT and HMGCR can significantly affect the drug-metabolizing process of HMG-CoA reductase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 13 Digestive system diseases
ICD-11: DC11 Gallstone disease		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Sterol element-binding 2 (SREBF2)		Gallstone disease		Activation
Uniprot ID	SRBP2_HUMAN
Interaction Name	SREBF2-HMGCR interaction				[3]
Studied Cell Lines	Gallstone disease liver tissue
Ensembl ID	ENSG00000198911
Description	Sterol element-binding 2 (SREBF2) is reported to activate the transcription of HMGCR gene, which leads to an increased expression of the drug-metabolizing enzyme HMG-CoA reductase. As a result, the interaction between SREBF2 and HMGCR can activate the drug-metabolizing process of HMG-CoA reductase.

References
1	Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. mBio. 2015 Dec 8;6(6):e01500-15.
2	Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis. Acta Pharmacol Sin. 2017 May;38(5):660-671.
3	Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression. Biochem Biophys Res Commun. 2007 Jun 8;357(3):707-11.

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