Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0225)
DME Name Cytosolic phospholipase A2 (PLA2G4A), Homo sapiens DME Info
UniProt ID
PA24A_HUMAN
EC Number    EC: 3.1.1.4     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A11 Brain neuroblastoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Neuroblastoma Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-PLA2G4A interaction [1]
Studied Cell Lines Human neuroblastoma cells SH-SY5Y
Description Histone deacetylases (HDACs) are reported to deacetylate the PLA2G4A gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cytosolic phospholipase A2. As a result, the interaction between HDACs and PLA2G4A can inhibit the drug-metabolizing process of Cytosolic phospholipase A2.
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Moderate hypermethylation
Interaction Name DNMT-PLA2G4A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypermethylation
p-value: 1.51E-07; delta-beta: 2.49E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PLA2G4A gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytosolic phospholipase A2. As a result, the interaction between DNMT and PLA2G4A can moderatly affect the drug-metabolizing process of Cytosolic phospholipase A2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
References
1 Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. Mol Neurobiol. 2016 Aug;53(6):3854-3872.

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