| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| Microphthalmia-associated TF (MITF) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
MITF-ACP5 interaction |
[1], [2] |
| Studied Cell Lines |
NIH 3T3 and COS-7 cell lines |
| Ensembl ID |
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| Description |
Microphthalmia-associated TF (MITF) is reported to activate the transcription of ACP5 gene, which leads to an increased expression of the drug-metabolizing enzyme Tartrate-resistant acid ATPase. As a result, the interaction between MITF and ACP5 can activate the drug-metabolizing process of Tartrate-resistant acid ATPase. |
| TF factor PU.1 (SPI1) |
Health |
Activation |
| Uniprot ID |
|
| Interaction Name |
SPI1-ACP5 interaction |
[1] |
| Studied Cell Lines |
NIH 3T3 cell line |
| Ensembl ID |
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| Description |
TF factor PU.1 (SPI1) is reported to activate the transcription of ACP5 gene, which leads to an increased expression of the drug-metabolizing enzyme Tartrate-resistant acid ATPase. As a result, the interaction between SPI1 and ACP5 can activate the drug-metabolizing process of Tartrate-resistant acid ATPase. |
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