Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0244) | |||||
|---|---|---|---|---|---|
| DME Name | Eosinophil peroxidase (EPX), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.11.1.7 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.11E-04; delta-beta: -2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.80E-64; delta-beta: -4.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPX gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.35E-15; delta-beta: -3.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPX gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.49E-05; delta-beta: 2.63E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the EPX gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.55E-15; delta-beta: -3.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPX gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.27E-05; delta-beta: -3.63E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPX gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.45E-21; delta-beta: -2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.57E-15; delta-beta: -3.49E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the EPX gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.38E-02; delta-beta: -2.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 3.27E-12; delta-beta: -2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.64E-06; delta-beta: 3.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the EPX gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can significantly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.34E-06; delta-beta: 2.24E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the EPX gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.86E-32; delta-beta: -2.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the EPX gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypermethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.98E-04; delta-beta: 2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the EPX gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-EPX interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.97E-09; delta-beta: 2.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the EPX gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Eosinophil peroxidase. As a result, the interaction between DNMT and EPX can moderatly affect the drug-metabolizing process of Eosinophil peroxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.