Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0246) | |||||
|---|---|---|---|---|---|
| DME Name | Lactoperoxidase (LPO), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.11.1.7 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.96E-11; delta-beta: -5.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.12E-27; delta-beta: -8.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.20E-02; delta-beta: 2.04E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the LPO gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can moderatly affect the drug-metabolizing process of Lactoperoxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.41E-07; delta-beta: -3.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 3.89E-02; delta-beta: 3.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the LPO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.69E-04; delta-beta: -4.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypomethylation p-value: 1.19E-17; delta-beta: -4.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can significantly affect the drug-metabolizing process of Lactoperoxidase. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 3.67E-02; delta-beta: -2.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can moderatly affect the drug-metabolizing process of Lactoperoxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C60 Breast cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Histone modification | |||||
| Histone deacetylases (HDACs) | Breast cancer | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HDACs-LPO interaction | [1] | |||
| Studied Cell Lines | MCF-7 cell line | ||||
| Description | Histone deacetylases (HDACs) are reported to deacetylate the LPO gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between HDACs and LPO can inhibit the drug-metabolizing process of Lactoperoxidase. | ||||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.32E-02; delta-beta: 2.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the LPO gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can moderatly affect the drug-metabolizing process of Lactoperoxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-LPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.34E-03; delta-beta: -2.49E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactoperoxidase. As a result, the interaction between DNMT and LPO can moderatly affect the drug-metabolizing process of Lactoperoxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| References | |||||
|---|---|---|---|---|---|
| 1 | Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. J Endocrinol Invest. 2010 Jan;33(1):2-6. | ||||
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