Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0283) | |||||
|---|---|---|---|---|---|
| DME Name | Dimethylaniline oxidase 2 (FMO2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.13.8 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 11 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.81E-22; delta-beta: 2.42E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FMO2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.20E-12; delta-beta: -3.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.08E-24; delta-beta: -4.04E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.59E-04; delta-beta: -2.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FMO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.26E-09; delta-beta: 4.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.36E-08; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FMO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.05E-30; delta-beta: -3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.30E-06; delta-beta: -2.53E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FMO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.73E-41; delta-beta: -3.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.71E-09; delta-beta: -2.04E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FMO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.16E-16; delta-beta: 4.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.11E-12; delta-beta: 4.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.74E-02; delta-beta: 2.19E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FMO2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B60 Squamous cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Squamous cell carcinoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 1.13E-03; delta-beta: 2.55E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FMO2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.87E-02; delta-beta: 7.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.14E-05; delta-beta: 4.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.96E-04; delta-beta: 2.53E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FMO2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can moderatly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.53E-56; delta-beta: -3.73E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.87E-02; delta-beta: 3.45E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.68E-08; delta-beta: 4.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.70E-23; delta-beta: -4.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FMO2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-FMO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 3.22E-02; delta-beta: 4.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FMO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylaniline oxidase 2. As a result, the interaction between DNMT and FMO2 can significantly affect the drug-metabolizing process of Dimethylaniline oxidase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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