Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0286)
DME Name Aldehyde dehydrogenase 1 (ALDH1), Homo sapiens DME Info
UniProt ID
AL1A1_HUMAN
EC Number    EC: 1.2.1.36     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.36
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Health Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-ALDH1 interaction [1]
Studied Cell Lines HEK293 cell line
Description Histone deacetylases (HDACs) are reported to deacetylate the ALDH1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Aldehyde dehydrogenase 1. As a result, the interaction between HDACs and ALDH1 can inhibit the drug-metabolizing process of Aldehyde dehydrogenase 1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C10 Pancreatic adenocarcinoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Oligomerization
                            Retinal dehydrogenase 1 (ALDH1A1) Pancreatic adenocarcinoma Homotetramer
Uniprot ID
AL1A1_HUMAN
Interaction Name ALDH1A1-ALDH1A1 homotetramerization [2]
Studied Cell Lines BxPC3, Panc1, and HEK293 cell lines
Description Retinal dehydrogenase 1 (ALDH1A1) is reported to homotetramerize with the ALDH1 protein, which leads to a suppressed activity of the drug-metabolizing enzyme Aldehyde dehydrogenase 1. As a result, the interaction between ALDH1A1 and ALDH1 can inhibit the drug-metabolizing process of Aldehyde dehydrogenase 1.
               ICD-11: 2C73 Ovarian cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Enhancer of zeste homolog 2 (EZH2) Ovarian cancer Repression
Uniprot ID
EZH2_HUMAN
Interaction Name EZH2-ALDH1A1 interaction [3]
Studied Cell Lines SKOV3 cell line
Description Enhancer of zeste homolog 2 (EZH2) is reported to repress the transcription of ALDH1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Aldehyde dehydrogenase 1. As a result, the interaction between EZH2 and ALDH1 can repress the drug-metabolizing process of Aldehyde dehydrogenase 1.
               ICD-11: 2E65 Ductal carcinoma in situ Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-140-5p Ductal carcinoma in situ Suppression
miRBase ID
MIMAT0000431
Interaction Name hsa-miR-140-5p--ALDH1A1 regulation [4]
Studied Cell Lines SUM225CWN and SUM102PT cell lines
Description hsa-miR-140-5p is reported to suppress ALDH1A1 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALDH1A1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Aldehyde dehydrogenase 1.
References
1 Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells. Int J Mol Med. 2017 Sep;40(3):661-672.
2 Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer. BMC Biol. 2017 Feb 13;15(1):10.
3 ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. Cancer Prev Res (Phila). 2012 Mar;5(3):484-91.
4 Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. Oncogene. 2014 May 15;33(20):2589-600.

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