Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0287)
DME Name Retinal dehydrogenase 2 (ALDH1A2), Homo sapiens DME Info
UniProt ID
AL1A2_HUMAN
EC Number    EC: 1.2.1.36     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.36
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A90 Mature T-cell lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Stem cell protein (TAL1) T-cell acute lymphoblastic leukemia Activation
Uniprot ID
TAL1_HUMAN
Interaction Name TAL1-ALDH1A2 interaction [1]
Studied Cell Lines T-ALL cell line
Ensembl ID
ENSG00000162367
Description Stem cell protein (TAL1) is reported to activate the transcription of ALDH1A2 gene, which leads to an increased expression of the drug-metabolizing enzyme Retinal dehydrogenase 2. As a result, the interaction between TAL1 and ALDH1A2 can activate the drug-metabolizing process of Retinal dehydrogenase 2.
References
1 TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998 Dec;18(12):6939-50.

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