| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Proto-oncogene c-Myb (MYB) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
MYB-GSTM1 interaction |
[1] |
| Studied Cell Lines |
Estrogen-regulated Myb-transformed cell line |
| Ensembl ID |
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| Description |
Proto-oncogene c-Myb (MYB) is reported to activate the transcription of GSTM1 gene, which leads to an increased expression of the drug-metabolizing enzyme Glutathione S-transferase mu-1. As a result, the interaction between MYB and GSTM1 can activate the drug-metabolizing process of Glutathione S-transferase mu-1. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B01 Cutaneous T Cell Lymphoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone acetyltransferases (HATs) |
Cutaneous T Cell Lymphoma |
Activation |
| Uniprot ID |
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| Interaction Name |
HATs-GSTM1 interaction |
[2] |
| Studied Cell Lines |
T cells from 39 pre/post-treatment peripheral blood samples |
| Description |
Histone acetyltransferases (HATs) are reported to acetylate the GSTM1 gene and thereby activate the transcriptional activity of the drug-metabolizing enzyme Glutathione S-transferase mu-1. As a result, the interaction between HATs and GSTM1 can enhance the drug-metabolizing process of Glutathione S-transferase mu-1. |
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