Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0314) | |||||
|---|---|---|---|---|---|
| DME Name | Glutathione S-transferase omega-2 (GSTO2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GSTO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.00E-03; delta-beta: -2.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase omega-2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-GSTO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.39E-02; delta-beta: 3.23E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can significantly affect the drug-metabolizing process of Glutathione S-transferase omega-2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypermethylation | |||
| Interaction Name | DNMT-GSTO2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.07E-04; delta-beta: 4.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can significantly affect the drug-metabolizing process of Glutathione S-transferase omega-2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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