General Information of Drug-Metabolizing Enzyme (DME ID: DME0314)
DME Name Glutathione S-transferase omega-2 (GSTO2), Homo sapiens DME Info
UniProt ID
GSTO2_HUMAN
EC Number    EC: 2.5.1.18     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Third ventricle chordoid glioma Moderate hypomethylation
Interaction Name DNMT-GSTO2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.00E-03; delta-beta: -2.84E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GSTO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can moderatly affect the drug-metabolizing process of Glutathione S-transferase omega-2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Liver cancer Significant hypermethylation
Interaction Name DNMT-GSTO2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 1.39E-02; delta-beta: 3.23E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can significantly affect the drug-metabolizing process of Glutathione S-transferase omega-2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanoma Significant hypermethylation
Interaction Name DNMT-GSTO2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 4.07E-04; delta-beta: 4.27E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GSTO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Glutathione S-transferase omega-2. As a result, the interaction between DNMT and GSTO2 can significantly affect the drug-metabolizing process of Glutathione S-transferase omega-2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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