Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0380) | |||||
|---|---|---|---|---|---|
| DME Name | Sulfotransferase 1B1 (SULT1B1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.8.2.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.94E-33; delta-beta: 2.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can moderatly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.48E-03; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can moderatly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.42E-12; delta-beta: 7.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can significantly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.95E-09; delta-beta: 2.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can moderatly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.43E-07; delta-beta: 2.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can moderatly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.87E-04; delta-beta: 2.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1B1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can moderatly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1B1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 7.26E-13; delta-beta: 4.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1B1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1B1. As a result, the interaction between DNMT and SULT1B1 can significantly affect the drug-metabolizing process of Sulfotransferase 1B1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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