Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0383) | |||||
|---|---|---|---|---|---|
| DME Name | Sulfotransferase 1C4 (SULT1C4), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.8.2.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 13 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.12E-05; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.94E-08; delta-beta: -2.42E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.83E-09; delta-beta: -2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.44E-06; delta-beta: -2.97E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.04E-03; delta-beta: -2.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.06E-05; delta-beta: -2.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.87E-12; delta-beta: -2.76E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.98E-12; delta-beta: -2.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.36E-29; delta-beta: -2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.56E-05; delta-beta: -2.97E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.15E-18; delta-beta: -2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.90E-13; delta-beta: -3.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SULT1C4 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.50E-10; delta-beta: 4.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.88E-19; delta-beta: 4.87E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.81E-02; delta-beta: 3.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.27E-26; delta-beta: 4.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 4.29E-04; delta-beta: 3.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.05E-07; delta-beta: 5.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.68E-04; delta-beta: 2.31E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1C4 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 4.46E-03; delta-beta: -2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.66E-07; delta-beta: 4.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.11E-39; delta-beta: -2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the SULT1C4 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.03E-06; delta-beta: 4.35E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the SULT1C4 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can significantly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypermethylation | |||
| Interaction Name | DNMT-SULT1C4 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.80E-02; delta-beta: 2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the SULT1C4 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Sulfotransferase 1C4. As a result, the interaction between DNMT and SULT1C4 can moderatly affect the drug-metabolizing process of Sulfotransferase 1C4. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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