| General Information of Drug-Metabolizing Enzyme (DME ID: DME0384) |
| DME Name |
Sulfotransferase 2B1 (SULT2B1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.8.2.2 (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfotransferase
EC: 2.8.2.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Health |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-SULT2B1 interaction |
[1] |
| Studied Cell Lines |
Immortalized human keratinocytes |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the SULT2B1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Sulfotransferase 2B1. As a result, the interaction between HDACs and SULT2B1 can inhibit the drug-metabolizing process of Sulfotransferase 2B1. |
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| References |
| 1 |
Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. FEBS Lett. 2005 Jul 4;579(17):3639-45.
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