Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0398) | |||||
|---|---|---|---|---|---|
| DME Name | Small intestine reductase (AKR1B10), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.21 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.30E-22; delta-beta: -4.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.19E-10; delta-beta: -2.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AKR1B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can moderatly affect the drug-metabolizing process of Small intestine reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.62E-12; delta-beta: -2.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AKR1B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can moderatly affect the drug-metabolizing process of Small intestine reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.33E-03; delta-beta: -3.61E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.73E-15; delta-beta: -5.96E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.31E-04; delta-beta: -2.85E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AKR1B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can moderatly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.45E-26; delta-beta: -4.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypomethylation p-value: 8.47E-24; delta-beta: -4.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.36E-34; delta-beta: -4.36E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypomethylation p-value: 3.46E-16; delta-beta: -4.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Significant hypermethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 3.53E-03; delta-beta: 1.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AKR1B10 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.84E-28; delta-beta: -8.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.37E-28; delta-beta: -6.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.20E-07; delta-beta: -6.91E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.30E-13; delta-beta: -3.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can significantly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 15 Musculoskeletal system diseases | |||||
| ICD-11: FA00 Osteoarthritis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Osteoarthritis | Moderate hypomethylation | |||
| Interaction Name | DNMT-AKR1B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.21E-19; delta-beta: -2.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AKR1B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Small intestine reductase. As a result, the interaction between DNMT and AKR1B10 can moderatly affect the drug-metabolizing process of Small intestine reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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