General Information of Drug-Metabolizing Enzyme (DME ID: DME0402)
DME Name Arachidonate 12-lipoxygenase (ALOX12B), Homo sapiens DME Info
UniProt ID
LX12B_HUMAN
EC Number    EC: 1.13.11.31     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.31
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        5 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Medulloblastoma Moderate hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.80E-108; delta-beta: -2.71E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ALOX12B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can moderatly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Brain neuroblastoma Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.84E-22; delta-beta: -4.05E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Central neurocytoma Moderate hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 3.60E-11; delta-beta: -2.08E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ALOX12B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can moderatly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Multilayered rosettes embryonal tumour Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 7.83E-21; delta-beta: -3.46E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
                            DNA methyltransferase (DNMT) Cerebellar liponeurocytoma Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 4.99E-11; delta-beta: -7.43E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.41E-11; delta-beta: -3.96E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Liver cancer Moderate hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.07E-07; delta-beta: -2.39E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ALOX12B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can moderatly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue Moderate hypomethylation
p-value: 1.18E-16; delta-beta: -2.53E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ALOX12B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can moderatly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2C25 Lung cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lung cancer Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 4.33E-33; delta-beta: -3.00E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
The Methylation Level of Disease Section Compare with the Other Disease Section Moderate hypomethylation
p-value: 3.10E-32; delta-beta: -2.97E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ALOX12B gene, which leads to a on moderatly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can moderatly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2D50 Brain cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Esthesioneuroblastoma Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.97E-21; delta-beta: -3.92E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 2F9A Endocrine gland cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Craniopharyngioma Significant hypomethylation
Interaction Name DNMT-ALOX12B interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.93E-18; delta-beta: -3.25E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALOX12B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arachidonate 12-lipoxygenase. As a result, the interaction between DNMT and ALOX12B can significantly affect the drug-metabolizing process of Arachidonate 12-lipoxygenase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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