Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0403)
DME Name	Arachidonate 15-lipoxygenase (ALOX15), Homo sapiens	DME Info
UniProt ID	LOX15_HUMAN
EC Number	EC: 1.13.11.33 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen single donor oxidoreductase Oxygen single donor oxidoreductase EC: 1.13.11.33
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A11 Brain neuroblastoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Neuroblastoma	Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-ALOX15 interaction			[1]
Studied Cell Lines	SH-SY5Y cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the ALOX15 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Arachidonate 15-lipoxygenase. As a result, the interaction between HDACs and ALOX15 can inhibit the drug-metabolizing process of Arachidonate 15-lipoxygenase.
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
Transcription-factor regulation
CREB-binding protein (CREBBP)		Lung cancer	Activation
Uniprot ID	CBP_HUMAN
Interaction Name	CREBBP-ALOX15 interaction			[2]
Studied Cell Lines	A549 cell line
Description	CREB-binding protein (CREBBP) is reported to activate the transcription of ALOX15 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 15-lipoxygenase. As a result, the interaction between CREBBP and ALOX15 can activate the drug-metabolizing process of Arachidonate 15-lipoxygenase.
His-acetyltransferase p300 (EP300)		Lung cancer	Activation
Uniprot ID	EP300_HUMAN
Interaction Name	EP300-ALOX15 interaction			[2]
Studied Cell Lines	A549 cell line
Description	His-acetyltransferase p300 (EP300) is reported to activate the transcription of ALOX15 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 15-lipoxygenase. As a result, the interaction between EP300 and ALOX15 can activate the drug-metabolizing process of Arachidonate 15-lipoxygenase.
STAT 6 (STAT6)		Lung cancer	Activation
Uniprot ID	STAT6_HUMAN
Interaction Name	STAT6-ALOX15 interaction			[2]
Studied Cell Lines	A549 cell line
Ensembl ID	ENSG00000166888
Description	STAT 6 (STAT6) is reported to activate the transcription of ALOX15 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 15-lipoxygenase. As a result, the interaction between STAT6 and ALOX15 can activate the drug-metabolizing process of Arachidonate 15-lipoxygenase.
TF factor PU.1 (SPI1)		Lung cancer	Activation
Uniprot ID	SPI1_HUMAN
Interaction Name	SPI1-ALOX15 interaction			[3]
Studied Cell Lines	A549 cell line
Ensembl ID	ENSG00000066336
Description	TF factor PU.1 (SPI1) is reported to activate the transcription of ALOX15 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 15-lipoxygenase. As a result, the interaction between SPI1 and ALOX15 can activate the drug-metabolizing process of Arachidonate 15-lipoxygenase.

References
1	Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochem Res. 2018 Mar;43(3):540-555.
2	IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor. J Immunol. 2003 Jan 15;170(2):887-94.
3	Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1. Hum Mutat. 2006 Jan;27(1):78-87

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