Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0405) | |||||
|---|---|---|---|---|---|
| DME Name | Copper amine oxidase (AOC3), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.4.3.21 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.72E-88; delta-beta: -3.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AOC3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.88E-29; delta-beta: -6.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AOC3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Vestibular melanotic schwannoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.03E-02; delta-beta: 2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AOC3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can moderatly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.17E-11; delta-beta: -2.42E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AOC3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can moderatly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.02E-03; delta-beta: -2.55E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AOC3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can moderatly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.88E-29; delta-beta: -2.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AOC3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can moderatly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.12E-11; delta-beta: -3.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AOC3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 2.26E-02; delta-beta: 3.19E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AOC3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.80E-12; delta-beta: 3.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AOC3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 2.35E-10; delta-beta: 3.80E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AOC3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Significant hypermethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 4.94E-02; delta-beta: 7.34E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AOC3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.11E-29; delta-beta: -5.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AOC3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BB01 Pulmonary hypertension | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pulmonary hypertension | Significant hypomethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.13E-02; delta-beta: -4.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AOC3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-AOC3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 3.44E-03; delta-beta: 3.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AOC3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Copper amine oxidase. As a result, the interaction between DNMT and AOC3 can significantly affect the drug-metabolizing process of Copper amine oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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