| General Information of Drug-Metabolizing Enzyme (DME ID: DME0408) |
| DME Name |
Arsenite methyltransferase (AS3MT), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.1.1.137 (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.137
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone methyltransferases (HMTs) |
Health |
Repression |
| Uniprot ID |
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| Interaction Name |
HMTs-AS3MT interaction |
[1] |
| Studied Cell Lines |
Human peripheral blood mononuclear cells |
| Description |
Histone methyltransferases (HMTs) are reported to hyper-methylate the AS3MT gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Arsenite methyltransferase. As a result, the interaction between HMTs and AS3MT can inhibit the drug-metabolizing process of Arsenite methyltransferase. |
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| References |
| 1 |
Differential methylation of the arsenic (III) methyltransferase promoter according to arsenic exposure. Arch Toxicol. 2014 Feb;88(2):275-82.
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