| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2A60 Acute myeloid leukemia |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Acute myeloid leukemia |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-CA2 interaction |
[1] |
| Studied Cell Lines |
Erythroleukemia cell line HD3 |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the CA2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Carbonic anhydrase II. As a result, the interaction between HDACs and CA2 can inhibit the drug-metabolizing process of Carbonic anhydrase II. |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-23b-3p |
Liver cancer |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-23b-3p--CA2 regulation |
[2] |
| Studied Cell Lines |
Hepatocellular carcinoma cells |
| Description |
hsa-miR-23b-3p is reported to suppress CA2 mRNA translation by binding to the 3' untranslated region (3'UTR) of CA2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Carbonic anhydrase II. |
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