Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0410)
DME Name Serine sulfhydrase (CBS), Homo sapiens DME Info
UniProt ID
CBS_HUMAN
EC Number    EC: 4.2.1.22     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.22
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Significant hypermethylation
Interaction Name DNMT-CBS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 6.73E-21; delta-beta: 6.26E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CBS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Serine sulfhydrase. As a result, the interaction between DNMT and CBS can significantly affect the drug-metabolizing process of Serine sulfhydrase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2B5J Fibrosarcoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Nuclear TF factor Y alpha (NFYA) Fibrosarcoma Activation
Uniprot ID
NFYA_HUMAN
Interaction Name NFYA-CBS interaction [1]
Studied Cell Lines HT1080 cell line
Ensembl ID
ENSG00000001167
Description Nuclear TF factor Y alpha (NFYA) is reported to activate the transcription of CBS gene, which leads to an increased expression of the drug-metabolizing enzyme Serine sulfhydrase. As a result, the interaction between NFYA and CBS can activate the drug-metabolizing process of Serine sulfhydrase.
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Nuclear TF factor Y alpha (NFYA) Liver cancer Activation
Uniprot ID
NFYA_HUMAN
Interaction Name NFYA-CBS interaction [1]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000001167
Description Nuclear TF factor Y alpha (NFYA) is reported to activate the transcription of CBS gene, which leads to an increased expression of the drug-metabolizing enzyme Serine sulfhydrase. As a result, the interaction between NFYA and CBS can activate the drug-metabolizing process of Serine sulfhydrase.
References
1 Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1. Biochim Biophys Acta. 2002 Dec 12;1579(2-3):73-80.

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