Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0413)
DME Name Delta(24)-sterol reductase (DHCR24), Homo sapiens DME Info
UniProt ID
DHC24_HUMAN
EC Number    EC: 1.3.1.72     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.72
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp1 (SP1) Liver cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-DHCR24 interaction [1]
Studied Cell Lines HepG2 and RzM6 cell lines
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of DHCR24 gene, which leads to an increased expression of the drug-metabolizing enzyme Delta(24)-sterol reductase. As a result, the interaction between SP1 and DHCR24 can activate the drug-metabolizing process of Delta(24)-sterol reductase.
References
1 Hepatitis C virus promotes expression of the 3beta-hydroxysterol Delte24-reductase through Sp1. J Med Virol. 2012 May;84(5):733-46.

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