Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0414)
DME Name	Short-chain dehydrogenase/reductase retSDR1 (DHRS3), Homo sapiens	DME Info
UniProt ID	DHRS3_HUMAN
EC Number	EC: 1.1.1.300 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.300
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Oligomerization
Retinol dehydrogenase 10 (RDH10)		Health		Homooligomer
Uniprot ID	RDH10_HUMAN
Interaction Name	RDH10-DHRS3 homooligomerization				[1]
Studied Cell Lines	Human embryonic kidney cell line (HEK293)
Affected Substrate(s):	Reduction of retinaldehyde (Metabolic product: Retinol)
Description	Retinol dehydrogenase 10 (RDH10) is reported to homooligomerize with the DHRS3 protein, which leads to activation of the drug-metabolizing enzyme Short-chain dehydrogenase/reductase retSDR1. As a result, the interaction between RDH10 and DHRS3 can activate the drug-metabolizing process of Short-chain dehydrogenase/reductase retSDR1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypermethylation
Interaction Name	DNMT-DHRS3 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.33E-09; delta-beta: 3.29E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DHRS3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Short-chain dehydrogenase/reductase retSDR1. As a result, the interaction between DNMT and DHRS3 can significantly affect the drug-metabolizing process of Short-chain dehydrogenase/reductase retSDR1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis. J Biol Chem. 2017 Apr 7;292(14):5884-5897.

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