Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0416)
DME Name Friedreich ataxia protein (FXN), Homo sapiens DME Info
UniProt ID
FRDA_HUMAN
EC Number    EC: 1.16.3.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Metal ion oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.16.3.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Health Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-FXN interaction [1]
Studied Cell Lines Mouse Model
Description Histone deacetylases (HDACs) are reported to deacetylate the FXN gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Friedreich ataxia protein. As a result, the interaction between HDACs and FXN can inhibit the drug-metabolizing process of Friedreich ataxia protein.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B71 Gastric cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Gastric cancer Moderate hypermethylation
Interaction Name DNMT-FXN interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypermethylation
p-value: 4.48E-11; delta-beta: 2.26E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FXN gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein. As a result, the interaction between DNMT and FXN can moderatly affect the drug-metabolizing process of Friedreich ataxia protein.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section
Download DME methylation data in the tissue of healthy individual
      ICD Disease Classification 08 Nervous system diseases
               ICD-11: 8A03 Hereditary ataxia Click to Show/Hide the Full List of HOSPPI:        9 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-124-3p Friedreich's ataxia Suppression
miRBase ID
MIMAT0000422
Interaction Name hsa-miR-124-3p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-124-3p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-1270 Friedreich's ataxia Suppression
miRBase ID
MIMAT0005924
Interaction Name hsa-miR-1270--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-1270 is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-299-3p Friedreich's ataxia Suppression
miRBase ID
MIMAT0000687
Interaction Name hsa-miR-299-3p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-299-3p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-506-3p Friedreich's ataxia Suppression
miRBase ID
MIMAT0002878
Interaction Name hsa-miR-506-3p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-506-3p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-522-3p Friedreich's ataxia Suppression
miRBase ID
MIMAT0002868
Interaction Name hsa-miR-522-3p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-522-3p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-559 Friedreich's ataxia Suppression
miRBase ID
MIMAT0003223
Interaction Name hsa-miR-559--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-559 is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-589-5p Friedreich's ataxia Suppression
miRBase ID
MIMAT0004799
Interaction Name hsa-miR-589-5p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-589-5p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-620 Friedreich's ataxia Suppression
miRBase ID
MIMAT0003289
Interaction Name hsa-miR-620--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-620 is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
                            hsa-miR-624-3p Friedreich's ataxia Suppression
miRBase ID
MIMAT0004807
Interaction Name hsa-miR-624-3p--FXN regulation [2]
Studied Cell Lines Friedreich's ataxia cells
Description hsa-miR-624-3p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
      ICD Disease Classification 20 Developmental anomalies
               ICD-11: LA8Z Congenital heart disease Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-145-5p Congenital heart disease Suppression
miRBase ID
MIMAT0000437
Interaction Name hsa-miR-145-5p--FXN regulation [3]
Studied Cell Lines Congenital heart disease cells
Description hsa-miR-145-5p is reported to suppress FXN mRNA translation by binding to the 3' untranslated region (3'UTR) of FXN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Friedreich ataxia protein.
References
1 Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia. J Child Neurol. 2012 Sep;27(9):1164-73.
2 Genetic variations creating microRNA target sites in the FXN 3'-UTR affect frataxin expression in Friedreich ataxia. PLoS One. 2013;8(1):e54791.
3 MiRNA-145 Regulates the Development of Congenital Heart Disease Through Targeting FXN. Pediatr Cardiol. 2016 Apr;37(4):629-36.

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