| General Information of Drug-Metabolizing Enzyme (DME ID: DME0418) |
| DME Name |
Glutamine synthetase (GLUL), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 6.3.1.2 (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Amide synthase
EC: 6.3.1.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 13 Digestive system diseases |
| ICD-11: DD91 Irritable bowel syndrome |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-29a-3p |
Irritable bowel syndrome |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-29a-3p--GLUL regulation |
[1] |
| Studied Cell Lines |
Irritable Bowel Syndrome cell line |
| Description |
hsa-miR-29a-3p is reported to suppress GLUL mRNA translation by binding to the 3' untranslated region (3'UTR) of GLUL mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Glutamine synthetase. |
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| References |
| 1 |
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut. 2010 Jun;59(6):775-84.
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