| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| PPA receptor delta (PPARD) |
Health |
Repression |
| Uniprot ID |
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| Interaction Name |
PPARD-HSD11B2 interaction |
[2] |
| Studied Cell Lines |
Placental trophoblast cell line |
| Ensembl ID |
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| Description |
PPA receptor delta (PPARD) is reported to repress the transcription of HSD11B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Corticosteroid 11-beta-dehydrogenase 2. As a result, the interaction between PPARD and HSD11B2 can repress the drug-metabolizing process of Corticosteroid 11-beta-dehydrogenase 2. |
| Histone modification |
| Histone methyltransferases (HMTs) |
Health |
Activation |
| Uniprot ID |
|
| Interaction Name |
HMTs-HSD11B2 interaction |
[1] |
| Studied Cell Lines |
Rodent model |
| Description |
The Histone 3 lysine 36 trimethylation of HSD11B2 gene is reported to activate the transcriptional activity of the drug-metabolizing enzyme Corticosteroid 11-beta-dehydrogenase 2. As a result, the interaction between Histone methyltransferases (HMTs) and HSD11B2 can enhance the drug-metabolizing process of Corticosteroid 11-beta-dehydrogenase 2. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B90 Colorectal cancer |
Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
|
| Transcription-factor regulation |
| Early growth response 1 (EGR1) |
Colorectal cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
EGR1-HSD11B2 interaction |
[3] |
| Studied Cell Lines |
SW620 cell line |
| Ensembl ID |
|
| Description |
Early growth response 1 (EGR1) is reported to repress the transcription of HSD11B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Corticosteroid 11-beta-dehydrogenase 2. As a result, the interaction between EGR1 and HSD11B2 can repress the drug-metabolizing process of Corticosteroid 11-beta-dehydrogenase 2. |
| Nuclear factor kappa-B p105 (NFKB1) |
Colorectal cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
NFKB1-HSD11B2 interaction |
[3] |
| Studied Cell Lines |
SW620 cell line |
| Ensembl ID |
|
| Description |
Nuclear factor kappa-B p105 (NFKB1) is reported to repress the transcription of HSD11B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Corticosteroid 11-beta-dehydrogenase 2. As a result, the interaction between NFKB1 and HSD11B2 can repress the drug-metabolizing process of Corticosteroid 11-beta-dehydrogenase 2. |
| Transcription factor p65 (RELA) |
Colorectal cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
RELA-HSD11B2 interaction |
[3] |
| Studied Cell Lines |
SW620 cell line |
| Ensembl ID |
|
| Description |
Transcription factor p65 (RELA) is reported to activate the transcription of HSD11B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Corticosteroid 11-beta-dehydrogenase 2. As a result, the interaction between RELA and HSD11B2 can activate the drug-metabolizing process of Corticosteroid 11-beta-dehydrogenase 2. |
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