Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0420)
DME Name	Estradiol 17-beta-dehydrogenase 1 (HSD17B1), Homo sapiens	DME Info
UniProt ID	DHB1_HUMAN
EC Number	EC: 1.1.1.62 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.62
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanocytoma		Significant hypomethylation
Interaction Name	DNMT-HSD17B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.56E-09; delta-beta: -5.11E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between DNMT and HSD17B1 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Moderate hypomethylation
Interaction Name	DNMT-HSD17B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.41E-05; delta-beta: -2.41E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between DNMT and HSD17B1 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C75 Placenta cancer		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
Transcription-factor regulation
GATA-binding factor 3 (GATA3)		Choriocarcinoma		Repression
Uniprot ID	GATA3_HUMAN
Interaction Name	GATA3-HSD17B1 interaction				[1]
Studied Cell Lines	Choriocarcinoma cell line
Ensembl ID	ENSG00000107485
Description	GATA-binding factor 3 (GATA3) is reported to repress the transcription of HSD17B1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between GATA3 and HSD17B1 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
TF factor AP-2-alpha (TFAP2A)		Choriocarcinoma		Repression
Uniprot ID	AP2A_HUMAN
Interaction Name	TFAP2A-HSD17B1 interaction				[1]
Studied Cell Lines	Choriocarcinoma cell line
Ensembl ID	ENSG00000137203
Description	TF factor AP-2-alpha (TFAP2A) is reported to repress the transcription of HSD17B1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between TFAP2A and HSD17B1 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
Transcription factor Sp1 (SP1)		Choriocarcinoma		Activation
Uniprot ID	SP1_HUMAN
Interaction Name	SP1-HSD17B1 interaction				[1]
Studied Cell Lines	Choriocarcinoma cell line
Ensembl ID	ENSG00000185591
Description	Transcription factor Sp1 (SP1) is reported to activate the transcription of HSD17B1 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between SP1 and HSD17B1 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5A80 Polycystic ovary syndrome		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Polycystic ovary syndrome		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-HSD17B1 interaction				[2]
Studied Cell Lines	Primary bovine theca (TC) and granulosa (GC) cells
Description	Histone deacetylases (HDACs) are reported to deacetylate the HSD17B1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between HDACs and HSD17B1 can inhibit the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
ICD Disease Classification 18 Pregnancy/childbirth/the puerperium
ICD-11: JA24 Preeclampsia		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Non-coding RNA regulation
hsa-miR-210-3p		Preeclampsia		Suppression
miRBase ID	MIMAT0000267
Interaction Name	hsa-miR-210-3p--HSD17B1 regulation				[3]
Studied Cell Lines	Preeclampsia cells
Description	hsa-miR-210-3p is reported to suppress HSD17B1 mRNA translation by binding to the 3' untranslated region (3'UTR) of HSD17B1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1.
hsa-miR-518c-3p		Preeclampsia		Suppression
miRBase ID	MIMAT0002848
Interaction Name	hsa-miR-518c-3p--HSD17B1 regulation				[3]
Studied Cell Lines	Preeclampsia cells
Description	hsa-miR-518c-3p is reported to suppress HSD17B1 mRNA translation by binding to the 3' untranslated region (3'UTR) of HSD17B1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1.

References
1	The proximal promoter region of the gene encoding human 17beta-hydroxysteroid dehydrogenase type 1 contains GATA, AP-2, and Sp1 response elements: analysis of promoter function in choriocarcinoma cells. Endocrinology. 1997 Aug;138(8):3417-25.
2	The anti-epileptic drug valproic acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro. PLoS One. 2012;7(11):e49553.
3	Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia. Hypertension. 2012 Feb;59(2):265-73.

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