Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0420)
DME Name Estradiol 17-beta-dehydrogenase 1 (HSD17B1), Homo sapiens DME Info
UniProt ID
DHB1_HUMAN
EC Number    EC: 1.1.1.62     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.62
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanocytoma Significant hypomethylation
Interaction Name DNMT-HSD17B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.56E-09; delta-beta: -5.11E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between DNMT and HSD17B1 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Melanoma Moderate hypomethylation
Interaction Name DNMT-HSD17B1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 2.41E-05; delta-beta: -2.41E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between DNMT and HSD17B1 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C75 Placenta cancer Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     Transcription-factor regulation
                            GATA-binding factor 3 (GATA3) Choriocarcinoma Repression
Uniprot ID
GATA3_HUMAN
Interaction Name GATA3-HSD17B1 interaction [1]
Studied Cell Lines Choriocarcinoma cell line
Ensembl ID
ENSG00000107485
Description GATA-binding factor 3 (GATA3) is reported to repress the transcription of HSD17B1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between GATA3 and HSD17B1 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
                            TF factor AP-2-alpha (TFAP2A) Choriocarcinoma Repression
Uniprot ID
AP2A_HUMAN
Interaction Name TFAP2A-HSD17B1 interaction [1]
Studied Cell Lines Choriocarcinoma cell line
Ensembl ID
ENSG00000137203
Description TF factor AP-2-alpha (TFAP2A) is reported to repress the transcription of HSD17B1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between TFAP2A and HSD17B1 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
                            Transcription factor Sp1 (SP1) Choriocarcinoma Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-HSD17B1 interaction [1]
Studied Cell Lines Choriocarcinoma cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of HSD17B1 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between SP1 and HSD17B1 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
      ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
               ICD-11: 5A80 Polycystic ovary syndrome Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Polycystic ovary syndrome Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-HSD17B1 interaction [2]
Studied Cell Lines Primary bovine theca (TC) and granulosa (GC) cells
Description Histone deacetylases (HDACs) are reported to deacetylate the HSD17B1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1. As a result, the interaction between HDACs and HSD17B1 can inhibit the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 1.
      ICD Disease Classification 18 Pregnancy/childbirth/the puerperium
               ICD-11: JA24 Preeclampsia Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-210-3p Preeclampsia Suppression
miRBase ID
MIMAT0000267
Interaction Name hsa-miR-210-3p--HSD17B1 regulation [3]
Studied Cell Lines Preeclampsia cells
Description hsa-miR-210-3p is reported to suppress HSD17B1 mRNA translation by binding to the 3' untranslated region (3'UTR) of HSD17B1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1.
                            hsa-miR-518c-3p Preeclampsia Suppression
miRBase ID
MIMAT0002848
Interaction Name hsa-miR-518c-3p--HSD17B1 regulation [3]
Studied Cell Lines Preeclampsia cells
Description hsa-miR-518c-3p is reported to suppress HSD17B1 mRNA translation by binding to the 3' untranslated region (3'UTR) of HSD17B1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 1.
References
1 The proximal promoter region of the gene encoding human 17beta-hydroxysteroid dehydrogenase type 1 contains GATA, AP-2, and Sp1 response elements: analysis of promoter function in choriocarcinoma cells. Endocrinology. 1997 Aug;138(8):3417-25.
2 The anti-epileptic drug valproic acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro. PLoS One. 2012;7(11):e49553.
3 Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia. Hypertension. 2012 Feb;59(2):265-73.

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