Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0422)
DME Name	Estradiol 17-beta-dehydrogenase 2 (HSD17B2), Homo sapiens	DME Info
UniProt ID	DHB2_HUMAN
EC Number	EC: 1.1.1.62 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.62
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Transcription factor Sp1 (SP1)		Health		Activation
Uniprot ID	SP1_HUMAN
Interaction Name	SP1-HSD17B2 interaction				[1], [2]
Studied Cell Lines	Human endometrial epithelial cell line
Ensembl ID	ENSG00000185591
Description	Transcription factor Sp1 (SP1) is reported to activate the transcription of HSD17B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between SP1 and HSD17B2 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
Transcription factor Sp3 (SP3)		Health		Activation
Uniprot ID	SP3_HUMAN
Interaction Name	SP3-HSD17B2 interaction				[1], [2]
Studied Cell Lines	Human endometrial epithelial cell line
Ensembl ID	ENSG00000172845
Description	Transcription factor Sp3 (SP3) is reported to activate the transcription of HSD17B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between SP3 and HSD17B2 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Moderate hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.75E-07; delta-beta: -2.63E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Moderate hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.60E-06; delta-beta: -2.55E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Significant hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.15E-02; delta-beta: -3.24E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Gastric cancer		Significant hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Significant hypomethylation p-value: 1.74E-02; delta-beta: -4.25E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Colorectal cancer		Moderate hypermethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.78E-03; delta-beta: 2.27E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the HSD17B2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C76 Endometrial cancer		Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
Transcription-factor regulation
Retinoic acid receptor alpha (RARA)		Endometrial cancer		Activation
Uniprot ID	RARA_HUMAN
Interaction Name	RARA-HSD17B2 interaction				[1]
Studied Cell Lines	Ishikawa and RL95-2 cell lines
Ensembl ID	ENSG00000131759
Description	Retinoic acid receptor alpha (RARA) is reported to activate the transcription of HSD17B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between RARA and HSD17B2 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
Retinoid X receptor alpha (RXRA)		Endometrial cancer		Activation
Uniprot ID	RXRA_HUMAN
Interaction Name	RXRA-HSD17B2 interaction				[1]
Studied Cell Lines	Ishikawa and RL95-2 cell lines
Ensembl ID	ENSG00000186350
Description	Retinoid X receptor alpha (RXRA) is reported to activate the transcription of HSD17B2 gene, which leads to an increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between RXRA and HSD17B2 can activate the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
Transcription factor Sp1 (SP1)		Endometrial cancer		Repression
Uniprot ID	SP1_HUMAN
Interaction Name	SP1-HSD17B2 interaction				[1]
Studied Cell Lines	Ishikawa and RL95-2 cell lines
Ensembl ID	ENSG00000185591
Description	Transcription factor Sp1 (SP1) is reported to repress the transcription of HSD17B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between SP1 and HSD17B2 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
Transcription factor Sp2 (SP2)		Endometrial cancer		Repression
Uniprot ID	SP2_HUMAN
Interaction Name	SP2-HSD17B2 interaction				[1]
Studied Cell Lines	Ishikawa and RL95-2 cell lines
Ensembl ID	ENSG00000167182
Description	Transcription factor Sp2 (SP2) is reported to repress the transcription of HSD17B2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between SP2 and HSD17B2 can repress the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer		Moderate hypermethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 9.79E-04; delta-beta: 2.42E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the HSD17B2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F9A Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Craniopharyngioma		Significant hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.15E-05; delta-beta: -3.20E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5A61 Pituitary gland hypofunction		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Chordoma		Significant hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.13E-05; delta-beta: -4.08E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can significantly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Moderate hypomethylation
Interaction Name	DNMT-HSD17B2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.62E-12; delta-beta: -2.24E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Estradiol 17-beta-dehydrogenase 2. As a result, the interaction between DNMT and HSD17B2 can moderatly affect the drug-metabolizing process of Estradiol 17-beta-dehydrogenase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab. 2008 May;93(5):1915-23.
2	SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. Biol Reprod. 2006 Oct;75(4):605-14.

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