Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0424) | |||||
|---|---|---|---|---|---|
| DME Name | Keto-steroid reductase (HSD17B7), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.270 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Acute myeloid leukemia | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.30E-03; delta-beta: -2.50E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B7 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Keto-steroid reductase. As a result, the interaction between DNMT and HSD17B7 can moderatly affect the drug-metabolizing process of Keto-steroid reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 1.27E-02; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B7 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Keto-steroid reductase. As a result, the interaction between DNMT and HSD17B7 can moderatly affect the drug-metabolizing process of Keto-steroid reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.88E-02; delta-beta: -2.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B7 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Keto-steroid reductase. As a result, the interaction between DNMT and HSD17B7 can moderatly affect the drug-metabolizing process of Keto-steroid reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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