Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0425) | |||||
|---|---|---|---|---|---|
| DME Name | Methylsterol monooxygenase 1 (MSMO1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.13.72 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Non-coding RNA regulation | |||||
| hsa-miR-19a-3p | Prostate cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-19a-3p--MSMO1 regulation | [1] | |||
| Studied Cell Lines | LNCaP cell line | ||||
| Description | hsa-miR-19a-3p is reported to suppress MSMO1 mRNA translation by binding to the 3' untranslated region (3'UTR) of MSMO1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Methylsterol monooxygenase 1. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PLoS One. 2013;8(2):e56592. | ||||
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