Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0428) | |||||
|---|---|---|---|---|---|
| DME Name | Uracil phosphoribosyltransferase (UPRT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.4.2.9 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 9 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.42E-09; delta-beta: -2.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.06E-11; delta-beta: -3.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UPRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can significantly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.61E-10; delta-beta: -3.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UPRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can significantly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.51E-02; delta-beta: -2.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.76E-11; delta-beta: -2.24E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.60E-14; delta-beta: 2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.57E-09; delta-beta: 2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.20E-04; delta-beta: 2.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.10E-07; delta-beta: 3.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the UPRT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can significantly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.28E-17; delta-beta: 2.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.88E-09; delta-beta: 4.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the UPRT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can significantly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.43E-04; delta-beta: 2.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.42E-45; delta-beta: -3.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UPRT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can significantly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.05E-09; delta-beta: 2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.09E-09; delta-beta: -2.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 08 Nervous system diseases | |||||
| ICD-11: 8E49 Postviral fatigue syndrome | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Postviral fatigue syndrome | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.32E-04; delta-beta: -2.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPRT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypermethylation | |||
| Interaction Name | DNMT-UPRT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.59E-02; delta-beta: 2.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UPRT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uracil phosphoribosyltransferase. As a result, the interaction between DNMT and UPRT can moderatly affect the drug-metabolizing process of Uracil phosphoribosyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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