Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0429)
DME Name Prostaglandin reductase 1 (PTGR1), Homo sapiens DME Info
UniProt ID
PTGR1_HUMAN
EC Number    EC: 1.3.1.16     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.16
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-522-3p Breast cancer Suppression
miRBase ID
MIMAT0002868
Interaction Name hsa-miR-522-3p--PTGR1 regulation [1]
Studied Cell Lines MDA-MB-231 cell line
Description hsa-miR-522-3p is reported to suppress PTGR1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGR1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin reductase 1.
References
1 Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis. Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):625-633.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.