| General Information of Drug-Metabolizing Enzyme (DME ID: DME0430) |
| DME Name |
Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.1.3.48 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.48
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C60 Breast cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-200a-3p |
Breast cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-200a-3p--UBASH3B regulation |
[1] |
| Studied Cell Lines |
Triple-negative breast cancer cells |
| Description |
hsa-miR-200a-3p is reported to suppress UBASH3B mRNA translation by binding to the 3' untranslated region (3'UTR) of UBASH3B mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Tyrosine-protein phosphatase STS1/TULA2. |
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| References |
| 1 |
Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11121-6.
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