Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0437)
DME Name	Purine nucleoside phosphorylase (PNP), Homo sapiens	DME Info
UniProt ID	PNPH_HUMAN
EC Number	EC: 2.4.2.1 (Click to Show/Hide the Complete EC Tree) Transferase Glycosyltransferases Pentosyltransferase EC: 2.4.2.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Non-coding RNA regulation
hsa-miR-1-3p		Prostate cancer	Suppression
miRBase ID	MIMAT0000416
Interaction Name	hsa-miR-1-3p--PNP regulation			[1]
Studied Cell Lines	PC3 and DU145 cell lines
Description	hsa-miR-1-3p is reported to suppress PNP mRNA translation by binding to the 3' untranslated region (3'UTR) of PNP mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Purine nucleoside phosphorylase.
hsa-miR-133a-3p		Prostate cancer	Suppression
miRBase ID	MIMAT0000427
Interaction Name	hsa-miR-133a-3p--PNP regulation			[1]
Studied Cell Lines	PC3 and DU145 cell lines
Description	hsa-miR-133a-3p is reported to suppress PNP mRNA translation by binding to the 3' untranslated region (3'UTR) of PNP mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Purine nucleoside phosphorylase.

References
1	Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br J Cancer. 2012 Jan 17;106(2):405-13.

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