Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0438) | |||||
|---|---|---|---|---|---|
| DME Name | Phosphodiesterase 7B (PDE7B), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.4.53 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.35E-05; delta-beta: -2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PDE7B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can moderatly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.53E-08; delta-beta: -2.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PDE7B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can moderatly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Mixed neuronal-glial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.01E-08; delta-beta: -3.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE7B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.09E-11; delta-beta: -4.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE7B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.13E-05; delta-beta: -5.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE7B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.73E-10; delta-beta: -4.95E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE7B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.61E-14; delta-beta: 6.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PDE7B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.32E-03; delta-beta: -3.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE7B gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.28E-02; delta-beta: 3.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PDE7B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 8.14E-03; delta-beta: 3.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PDE7B gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can significantly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.09E-05; delta-beta: -2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PDE7B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can moderatly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypomethylation | |||
| Interaction Name | DNMT-PDE7B interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.36E-02; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PDE7B gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphodiesterase 7B. As a result, the interaction between DNMT and PDE7B can moderatly affect the drug-metabolizing process of Phosphodiesterase 7B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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