Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0442)
DME Name	Dihydropyrimidinase-related protein 1 (DRP1), Homo sapiens	DME Info
UniProt ID	DPYL1_HUMAN
EC Number	EC: 3.5.2.2 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.2
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-187-3p		Gastric cancer		Suppression
miRBase ID	MIMAT0000262
Interaction Name	hsa-miR-187-3p--CRMP1 regulation				[1]
Studied Cell Lines	Hs-746T cell line
Description	hsa-miR-187-3p is reported to suppress CRMP1 mRNA translation by binding to the 3' untranslated region (3'UTR) of CRMP1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dihydropyrimidinase-related protein 1.
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-DRP1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.75E-08; delta-beta: -2.02E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DRP1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dihydropyrimidinase-related protein 1. As a result, the interaction between DNMT and DRP1 can moderatly affect the drug-metabolizing process of Dihydropyrimidinase-related protein 1.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypomethylation p-value: 2.64E-11; delta-beta: -2.04E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DRP1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dihydropyrimidinase-related protein 1. As a result, the interaction between DNMT and DRP1 can moderatly affect the drug-metabolizing process of Dihydropyrimidinase-related protein 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section

References
1	MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1. Biochem Biophys Res Commun. 2017 Jan 22;482(4):597-603.

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