Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0445) | |||||
|---|---|---|---|---|---|
| DME Name | Nicotinamide N-methyltransferase (NNMT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.1.1.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.31E-04; delta-beta: -2.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NNMT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.75E-04; delta-beta: -4.80E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.80E-06; delta-beta: -3.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.68E-03; delta-beta: -3.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.67E-12; delta-beta: -2.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NNMT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypermethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.04E-05; delta-beta: 6.44E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NNMT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.24E-11; delta-beta: 2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NNMT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.34E-02; delta-beta: 2.44E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NNMT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 5.63E-16; delta-beta: 6.89E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NNMT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 4.00E-04; delta-beta: 2.52E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NNMT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.06E-05; delta-beta: -4.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.65E-61; delta-beta: -4.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.85E-02; delta-beta: -2.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NNMT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can moderatly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.23E-06; delta-beta: -3.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-NNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.34E-30; delta-beta: -9.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NNMT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Nicotinamide N-methyltransferase. As a result, the interaction between DNMT and NNMT can significantly affect the drug-metabolizing process of Nicotinamide N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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