Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0446) | |||||
|---|---|---|---|---|---|
| DME Name | Angiotensin-converting enzyme 2 (ACE2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.4.17.23 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification Healthy | |||||
| ICD-11: Healthy | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| ARNT-interacting protein (HIF1A) | Health | Repression | |||
| Uniprot ID | |||||
| Interaction Name | HIF1A-ACE2 interaction | [1] | |||
| Studied Cell Lines | Pulmonary artery smooth muscle cell line | ||||
| Ensembl ID | |||||
| Description | ARNT-interacting protein (HIF1A) is reported to repress the transcription of ACE2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between HIF1A and ACE2 can repress the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.86E-12; delta-beta: -6.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ACE2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can significantly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.47E-15; delta-beta: -5.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ACE2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can significantly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 3.01E-02; delta-beta: 4.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ACE2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can significantly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 2.18E-10; delta-beta: -2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACE2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can moderatly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.62E-03; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACE2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can moderatly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.27E-02; delta-beta: 4.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ACE2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can significantly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.32E-04; delta-beta: -3.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ACE2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can significantly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.37E-04; delta-beta: -2.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACE2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can moderatly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-ACE2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.60E-08; delta-beta: -2.47E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ACE2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Angiotensin-converting enzyme 2. As a result, the interaction between DNMT and ACE2 can moderatly affect the drug-metabolizing process of Angiotensin-converting enzyme 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| References | |||||
|---|---|---|---|---|---|
| 1 | Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L631-40. | ||||
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