Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0447)
DME Name Acid cholesteryl ester hydrolase (LIPA), Homo sapiens DME Info
UniProt ID
LICH_HUMAN
EC Number    EC: 3.1.1.13     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.13
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Third ventricle chordoid glioma Significant hypomethylation
Interaction Name DNMT-LIPA interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.61E-06; delta-beta: -4.50E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LIPA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Acid cholesteryl ester hydrolase. As a result, the interaction between DNMT and LIPA can significantly affect the drug-metabolizing process of Acid cholesteryl ester hydrolase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2A82 Chronic lymphocytic leukemia Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-125b-5p Chronic lymphocytic leukaemia Suppression
miRBase ID
MIMAT0000423
Interaction Name hsa-miR-125b-5p--LIPA regulation [1]
Studied Cell Lines MEC1 and MEC2 cell lines
Description hsa-miR-125b-5p is reported to suppress LIPA mRNA translation by binding to the 3' untranslated region (3'UTR) of LIPA mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Acid cholesteryl ester hydrolase.
References
1 The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood. 2012 Sep 27;120(13):2631-8.

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