Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0451)
DME Name Thyroid peroxidase (TPO), Homo sapiens DME Info
UniProt ID
PERT_HUMAN
EC Number    EC: 1.11.1.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.8
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Hepatocyte NF 3-beta (FOXA2) Health Activation
Uniprot ID
FOXA2_HUMAN
Interaction Name FOXA2-TPO interaction [1]
Studied Cell Lines Thyroid cell line
Ensembl ID
ENSG00000125798
Description Hepatocyte NF 3-beta (FOXA2) is reported to activate the transcription of TPO gene, which leads to an increased expression of the drug-metabolizing enzyme Thyroid peroxidase. As a result, the interaction between FOXA2 and TPO can activate the drug-metabolizing process of Thyroid peroxidase.
                            Transcription release 2 (TTF2) Health Activation
Uniprot ID
TTF2_HUMAN
Interaction Name TTF2-TPO interaction [1]
Studied Cell Lines Thyroid cell line
Description Transcription release 2 (TTF2) is reported to activate the transcription of TPO gene, which leads to an increased expression of the drug-metabolizing enzyme Thyroid peroxidase. As a result, the interaction between TTF2 and TPO can activate the drug-metabolizing process of Thyroid peroxidase.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2E06 Prostate cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Prostate cancer metastasis Moderate hypomethylation
Interaction Name DNMT-TPO interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 3.91E-02; delta-beta: -2.06E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Thyroid peroxidase. As a result, the interaction between DNMT and TPO can moderatly affect the drug-metabolizing process of Thyroid peroxidase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
References
1 Hepatocyte nuclear factor 3beta participates in the transcriptional regulation of the thyroperoxidase promoter. Biochem Biophys Res Commun. 1996 Mar 7;220(1):86-93.

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