| General Information of Drug-Metabolizing Enzyme (DME ID: DME0456) |
| DME Name |
Uridine/cytidine monophosphate kinase (UMPK), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.7.4.14 (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.4.14
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C73 Ovarian cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-130b-3p |
Ovarian cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-130b-3p--CMPK1 regulation |
[1] |
| Studied Cell Lines |
OVCAR-3 and SK-OV-3 cell lines |
| Description |
hsa-miR-130b-3p is reported to suppress CMPK1 mRNA translation by binding to the 3' untranslated region (3'UTR) of CMPK1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Uridine/cytidine monophosphate kinase. |
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| References |
| 1 |
Cytidine monophosphate kinase is inhibited by the TGF-beta signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer. Cell Signal. 2017 Jul;35:197-207.
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